Tumor Microenvironment Activated Vanadium−Doped Carbon Dots for Fluorescence Imaging and Chemodynamic Therapy

The multifunctional platform response to the tumor microenvironment (TME) is critical for high-precision diagnosis and treatment of cancer with low systemic toxicity. In this regard, vanadium-doped carbon dots (V−CDs) have been developed TME-activated fluorescence imaging chemodynamic therapy (CDT). Due Forster resonance energy transfer caused by doped vanadium, obtained V−CDs displayed quenched fluorescence. Once entering tumor, ability are stimulated reaction between vanadium overexpressed H2O2 in a weak acid TME. Meanwhile, hydroxyl radicals generated catalytic could induce oxidative damage cells CDT, while showing less cytotoxicity side effects normal cells. Therefore, well-designed be used CDT maintaining an “inactive” status tissues ensure biological toxicity, satisfying clinical requirements accurate efficient tumors. Our research provides effective strategy designing preparing nanotheranostic drugs responsive TME treatment.